Study: Diagnostic Scan for Dogs with Solid Tumor Type Cancer
Location: University of Florida
Phone: 352-392-2235 or Dr. Rowan Milner at firstname.lastname@example.org
The University of Florida College of Veterinary Medicine is currently recruiting dogs recently diagnosed with cancer for a
clinical research trial. This investigational trial is for the development of a future diagnostic imaging and drug delivery
Eligibility: Any dog recently diagnosed with cancer. All solid tumors will be considered that have not been surgically
Summary: The University of Florida is developing a unique method for delivering therapy to the tumor areas of dogs. This
method uses a polymer that has been made at UF to target tumor cells. A polymer is a string of molecules connected
together, like how plastic is made. This first study is testing the polymer drug delivery system to see if it attaches to your
dog’s tumor and to see if it attaches to other areas of the body that could also be cancer that has spread. There is no drug
attached to the polymer for this study. This polymer is water soluble and the body should process it normally. Attached to
this polymer is a radionuclide. A radionuclide is a chemical that can concentrate in certain tissues or organs and emit
gamma rays that can be measured with a camera. Radioactive Iodine to test the tisses in a thyroid gland is an example of
a common medical practice where this technique is used. For this styudy, the radionuclide allows us to see where the
polymer goes inside the body when we take pictures of the body using a special scanner. Blood and urine will be collected
throughout the duration of the study. This is not a cancer treatment study. Your dog will be available to further cancer
therapies after 24 hours.
Dogs will be dosed with a diagnostic radionuclide polymer and scanned with a machine that will take a picture of affected
areas to determine where in the body the drug went. This is not a treatment study. Dogs will be released from the trial and
be available for surgery or further cancer therapy after 24 hours.
Financial incentive: A $200 credit will be provided towards your bill for diagnosis or imaging.
Study: Phase I clinical trial of 5-fluorouracil in tumor-bearing dogs
Location: University of Georgia, Athens, GA
For more information, please contact Dr. Corey Saba, Dr. Jessica Lawrence, or Dr. Nicole Northrup at 1-(800)-861-7456,
locally at (706) 542-5362
- Dogs must be otherwise healthy, have adequate bone marrow and organ function, and weigh > 10.0 kg
- They may have measurable or microscopic disease to participate.
- They may have had prior surgery, radiotherapy, and/or chemotherapy. However, there must be at least a four week
lapse between any of these treatments and trial entry.
- Dogs may not receive non-steroidal anti-inflammatory drugs (NSAIDs) while in the study and must undergo a 72 hour
washout period if on NSAIDs prior to study initiation.
- Treatment with prednisone is permissible if indicated for the dog’s disease process.
- Owners must sign a consent form.
Summary: 5-fluoropyrimidime antimetabolite drugs such as 5-fluoruracil (5-FU) are primarily used in human oncology to
treat epithelial tumors. Although 5-FU has been used to treat cancer in dogs, its dosage, treatment schedule, and
toxicities have never been appropriately investigated. The objectives of this study are to determine the maximum tolerated
dosage, to establish a safe starting dosage, and to determine treatment-related side effects of 5-FU in dogs with cancer.
Dogs must have a confirmed diagnosis of malignant cancer to be eligible for participation in this study.
Requirements and Incentives: Dogs will undergo preliminary staging tests including initial consultation and physical
examination, complete blood count (CBC), serum biochemical profile, and urinalysis to determine trial eligibility. Once
accepted into the study, the intent will be to administer escalating dosages of 5-FU to each dog at weekly intervals for up to
four treatments total. A CBC will be rechecked prior to each treatment. Additionally, blood will be collected prior to the
first treatment to determine 5-FU clearance.
Owners will be responsible for the costs of all office visits, the initial staging, and any related medications or diagnostic
tests. The costs of lab work (follow-up CBCs, biochemical profile, and 5-FU clearance samples), up to four 5-FU treatments
and associated chemotherapy administration fees will be paid by the study if the dog qualifies. Assuming the dog tolerates
the first four treatments well, treatments may be continued, off study, at the owner’s expense. Up to $500 is budgeted per
dog to treat severe complications of treatment (should they occur). Any costs greater than $500 will be the owner’s
Study: CTI-52010 as therapy for dogs with cancer
Location: Missouri University Veterinary Medical Teaching Hospital, Columbia, MO
Phone: 573-882-7821 (Dr.Kim Selting)
- Any tumor except OSA including lymphoma confirmed by histopathology or cytology
- Normal CBC, renal and liver function, UA and thoracic radiographs at first visit.
- 28 day washout from last chemotherapy
- Patient must weigh over 10 kgs
Summary: CTI-52010 is a new nanoparticle taxane drug that has been developed to avoid the allergic reactions of earlier
taxanes. It has already been shown to be safe in normal dogs. This clinical trial will refine the proper dosage for dogs with
cancer and determine whether there is evidence of efficacy.
CTI-52010 every 3 weeks for a total of 4 treatments
CBC, chemistry panel, UA on days 0, 7, 21, 28, 42, 49, 63 and 70. Thoracic radiographs on day 0 and 63, then every 2
months thereafter. Visits also on days 14, 35, 56 and 77.
Requirements and Financial Incentives: Once enrolled study is fully funded. Treatment includes: free drug and drug
administration, hospitalization for 1st night, blood work, imaging (rads & U/S) and office calls. Initial workup is owner’s
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Comprehensive guide to cancer diagnosis and treatment in cats and dogs
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Last updated 8/16/13
|Clinical trials for any tumor type in dogs
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