Study: Development of a Canine Model of Radiotherapy-Induced Oral Mucositis
Location: University of Pennsylvania Veterinary Hospital, Philadelphia, PA
Contact: 215-573-0302 or firstname.lastname@example.org
Eligibility: Dogs who have been diagnosed with cancer located in any structure in the head (mouth, nose, brain) . Dogs with
cancer of the neck (thyroid tumor, etc) are not eligible for the study at this time. You have elected to pursue radiation
therapy to treat your dog’s cancer
Summary: If your dog has been diagnosed with cancer of the head (including neoplasias of the oral and nasal cavity and
brain), he or she may be eligible to participate in our study. This study is looking at the development of sores in the mouth
(oral mucositis) that result as a side effect of radiation treatment. The purpose of this clinical research project is gather
data about the development and progression of oral mucositis and how it affects dogs’ behavior and quality of life. After
the data is collected, the results will be analyzed in the hope to develop more treatment options and relief for this condition.
Oral Mucositis (OM) is redness, inflamation or open sores inside the mouth and/or throat, caused by radiation therapy in
the treatment of cancer. Up to 90% of patients receiving radiotherapy for the treatment of cancer of the head or neck will
develop OM. OM causes pain and discomfort, leading to difficulties eating and swallowing, and interferes with sleeping,
which can decrease the patient's quality of life. It may also limit the amount of radiotherapy the patient can tolerate, which
may decrease the ability to cure the cancer. Dogs develop OM in much the same way as people do who are being treated
for head and neck cancer. The overwhelming similarities between OM in people and dogs suggests that studying OM in
dogs may be useful in developing prevention and treatment models for humans.
Requirements: You must be able to bring your dog to the hospital for his or her scheduled radiation treatments as
determined by the veterinarian and for weekly visits for four weeks following his or her final treatment. You will also be
asked to fill out questionnaires at each visit asking about your dog’s quality of life, general pain and mouth-related pain.
Costs: All radiation treatments and related anesthesia, bloodwork and x-rays will be paid for by the study. It is your
responsibility to obtain and pay for the initial cancer diagnosis, usually achieved by CT scan.
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Last updated 1/22/12
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