Study: Pegylated arginine deiminase for dogs with lymphoma or oral malignant melanoma
Location: University of California Veterinary Hospital Davis, CA
Phone: (530) 752-1393, ext 431
Eligibility: The dog must be examined by the VMTH Oncology or Radiation Oncology service veterinarian, and require the
following baseline evaluations at the owner's expense before a dog can be considered for enrollment in the trial:
• Confirmed diagnosis (histologically or cytologically)
• Physical examination with weight recorded
• CBC, Chemistry Panel and Urinalysis All within two weeks of enrollment (referring blood work is acceptable as long as it
was run at a commercial lab).
The dogs must also satisfy the following criteria:
• Measurable disease and tumor that can be biopsied
• Ability to stay overnight
• Dog has to be greater than 10kg
• Informed owner consent
Summary: The goal of this study is to evaluate the efficacy of using the enzyme Pegylated Arginine Deiminase (non-
chemotherapy drug) as a subcutaneous injection.
Financial incentives: This study is fully funded.
Study: Vaccine Study for Dogs with Melanoma
Location: University of Florida
Phone: 352-392-2235 or Dr. Rowan Milner at email@example.com
Eligibility: Any dog recently diagnosed witth malignant melanoma that is resectable or minimal and does not have other life
threatening diseases. The doctors will explain this to you.
Summary: Melanoma (cancer of pigment producing cells in the body) is malignant cancer in both humans and animals.
Some forms of melanoma in the dog follow a similar aggressive pathway as it does in humans. The main treatment for
melanoma in dogs is surgery, however this cancer often spreads in the body and shortens the survival time. Radiation
treatment and chemotherapy have been used in combination with surgery but results are still poor. Because this type of
cancer has been known to cause an immune reaction in people and in animals, developing a vaccine holds promise to use
in addition to surgery. Vaccines are often used because they stimulate a response inside the body to fight infection or
prevent infection. It is our hope that this vaccine will stimulate a response in the body to kill the cancer that is present. In
prior laboratory experiments and clinical trials in healthy dogs, we have seen that this vaccine causes the body to produce
a response that kills melanoma cells.
The University of Florida College of Veterinary Medicine is currently recruiting dogs recently diagnosed with malignant
melanoma for a clinical research trial. This investigational trial is for the development of a vaccine for the future treatment
or prevention of melanoma in dogs.
Participation involves 7 visits to the clinic in one year and follow up visits every 3 months following treatment. Blood will be
drawn on your dog’s first visit to compare with blood drawn later in the study. The vaccine will be given 3 times in 3
separate body locations approximately 4 weeks apart.
Financial incentive: The study will pay for the vaccine and costs associated with monitoring your dog’s immune response.
You are responsible to pay for office visits.
Study: Evaluation of DTIC chemotherapy for dogs with melanoma
Location: Tufts University Cummings School of Veterinary Medicine, North Grafton, MA
Phone: Kelly Reed, Oncology Liaison; (508) 887-4682
Eligibility: Dogs must have measurable tumor either at the primary site or metastasis and must be in good clinical condition.
Dog whose life expectancy is less than 3 months or whole have significant liver disease are ineligible.
Summary: DTIC is considered the gold standard of chemotherapy treatment for melanoma in people. The goal of this study
is to determine the efficacy of DTIC in treating dogs with this highly malignant cancer.
Requirement and incentive: The owner is financially responsible for all tests that determine if the patient qualifies for the
study. These tests may include initial specialty examination, chest x-rays, blood and urine tests. The study covers the cost
of two cycles of DTIC chemotherapy including re-check examination fee and cost of pre-treatment CBC/plt count.
Location: University of Wisconsin Veterinary Teaching Hospital, Madison, WI
Phone: (608) 263-7600
Summary: Malignant melanoma is a highly aggressive cancer that is resistant to standard chemotherapy. Surgery and/or
radiation therapy may control the primary tumor, but most dogs die within one year. Tyrosine kinases are proteins that play
a key role in regulation of cell growth. Evidence suggests that in humans and companion animals, tyrosine kinases are
often abnormally activated leading to uncontrolled cell growth. Masitinib is a tyrosine kinase inhibitor that has been found
to prolong the time to disease progression in dogs with mast cell tumors. The purpose of the proposed study is to evaluate
the antitumor activity of masitinib when given alone or in combination with currently available treatments for dogs with
melanoma. In the proposed studies, dogs with melanoma will be randomized to receive masitinib alone, Oncept (Canine
Melanoma Vaccine) alone, or masitinib combined with the chemotherapy drug doxorubicin. The cost of masitinib, Oncept,
and doxorubicin will be paid for by the study. Owners are responsible for the cost of the initial staging (approximately $400-
600), blood and urine tests, and examination fees.
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Last updated 3/21/12
|Clinical trials for melanoma in dogs
trials for dogs
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