Study: Canine Mammary Cancer Clinical Trial
Location: Auburn University Small Animal Hospital
Contact: 334-844-4690; Dr. Annette Smith at smith30@auburn.edu
www.vetmed.auburn.edu/home/practitioners/clinical-trials/canine-mammary-cancer
Summary: The Auburn University College of Veterinary Medicine is conducting clinical trials in canine breast/mammary
cancer to evaluate the effectiveness of a revolutionary new cell-based vaccine technology designed to enhance the patient’
s own immune recognition and response to mammary cancer. This treatment takes advantage of the latest research into
the biology of canine cancer. We are looking for dogs for potential recruitment in the clinical trial prior to treatment. We
encourage you to refer such cases, with a presumptive diagnosis of mammary cancer, for enrollment and treatment under
this protocol.
Eligibility: Dogs can be spayed or intact with diagnosed or suspected multifocal mammary cancer and should have no
evidence of tumor spread to the lungs on the basis of chest x-rays although lymph node involvement is acceptable.
Treatment: The treatment is composed of three vaccinations made from the patient’s own antigen presenting cells
(harvested from blood) and a canine mammary tumor-derived cell line in combination with other components designed to
enhance immune system recognition. The treatment has proven safe in normal laboratory dogs with few observable side-
effects which were low to moderate in severity and resolved quickly without further intervention. We hope our approach
provides a more effective management strategy than is currently available to practitioners.
Incentive: Standard treatment (surgery +/- chemotherapy) is covered by the trial and ideally will be performed at Auburn
University as we will require fresh and sterile biopsy materials to determine diagnosis and to culture tumor cells for follow-
up analysis of the patient’s immune response. Referral from the owner’s personal veterinarian or veterinary clinic is
preferred for enrollment. Post-surgical treatment, including all three vaccinations (the treatment protocol lasts
approximately 10-12 weeks) followed by three rechecks (during the remainder of one year) will be provided without charge
for qualified enrollees.
Location: Auburn University Small Animal Hospital
Contact: 334-844-4690; Dr. Annette Smith at smith30@auburn.edu
www.vetmed.auburn.edu/home/practitioners/clinical-trials/canine-mammary-cancer
Summary: The Auburn University College of Veterinary Medicine is conducting clinical trials in canine breast/mammary
cancer to evaluate the effectiveness of a revolutionary new cell-based vaccine technology designed to enhance the patient’
s own immune recognition and response to mammary cancer. This treatment takes advantage of the latest research into
the biology of canine cancer. We are looking for dogs for potential recruitment in the clinical trial prior to treatment. We
encourage you to refer such cases, with a presumptive diagnosis of mammary cancer, for enrollment and treatment under
this protocol.
Eligibility: Dogs can be spayed or intact with diagnosed or suspected multifocal mammary cancer and should have no
evidence of tumor spread to the lungs on the basis of chest x-rays although lymph node involvement is acceptable.
Treatment: The treatment is composed of three vaccinations made from the patient’s own antigen presenting cells
(harvested from blood) and a canine mammary tumor-derived cell line in combination with other components designed to
enhance immune system recognition. The treatment has proven safe in normal laboratory dogs with few observable side-
effects which were low to moderate in severity and resolved quickly without further intervention. We hope our approach
provides a more effective management strategy than is currently available to practitioners.
Incentive: Standard treatment (surgery +/- chemotherapy) is covered by the trial and ideally will be performed at Auburn
University as we will require fresh and sterile biopsy materials to determine diagnosis and to culture tumor cells for follow-
up analysis of the patient’s immune response. Referral from the owner’s personal veterinarian or veterinary clinic is
preferred for enrollment. Post-surgical treatment, including all three vaccinations (the treatment protocol lasts
approximately 10-12 weeks) followed by three rechecks (during the remainder of one year) will be provided without charge
for qualified enrollees.
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Last updated 1/22/12
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